Proteomics Informed by Transcriptomics

In collaboration with David Matthews of the University of Bristol we have pioneered the use of de novo transcript assemblies from RNA-seq data for the routine creation of sample-specific proteomes. This approach, coined “Proteomics Informed by Transcriptomics” (PIT), brings the power of proteomics to previously intractable applications, such as host-pathogen studies and metaproteomics experiments.

PIT paper in Nature Methods